In focus

One Health – working together for improved antibiotic use

One Health is often used as a buzzword – a word that evokes reactions and feels intuitively positive. Unfortunately, it is often poorly defined and understood. One attempt to define it is as a connectivity. The health of humans is connected to the health of animals and plants and vice versa. We all share this space, whether we call it a biome, ecosystem or Mother Earth.

ReAct - Action on Antibiotic Resistance

ReAct is an independent network dedicated to the problem of antibiotic resistance. ReAct is a global catalyst, advocating and stimulating for global engagement on antibiotic resistance through a broad range of collaborations.

ReAct Interview

Dr. Ravathi, Kenya on the WHO essential diagnostics list and what it means for Africa

In May of 2018, the WHO released the first-ever list of essential diagnostics to improve diagnosis and treatment outcomes to the delight of many champions of antimicrobial resistance across the globe. In Africa, the release of this list was particularly exciting to one doctor in Nairobi, Kenya, who has long been an advocate for the development of such a list.

Opinion

Antibiotic Resistance Coalition, including ReAct, responds to IACG discussion papers

During the summer the UN Interagency Coordination Group (IACG) released six discussion papers for public consultation to solicit feedback on the work of IACG to inform its future deliberations. Members of the Antibiotic Resistance Coalition (ARC), including ReAct, convened to discuss and submitted responses to the first set of discussion papers.

Opinion

Antibiotic Resistance Coalition, including ReAct, responds to the second round of IACG discussion papers

The Antibiotic Resistance Coalition (ARC) has again convened to review the second round of papers released by the UN Interagency Coordination Group on Antimicrobial Resistance (IACG). Earlier we shared the key takeaways from the responses on the first set of discussion papers, and here we summarize the main messages of the ARC responses to the second set of three papers.

News

CGIAR collaboration for the ReAct Toolbox

In the beginning of September, ReAct welcomed a group of researchers from the CGIAR network to Uppsala, Sweden for a workshop for the ReAct Toolbox. Together, we worked to identify existing resources and example case studies to inspire and facilitate action on antibiotic use and resistance in the farming sector.

Science

Ethical considerations regarding infection prevention control

The prospect of increasing spread of antibiotic resistant bacteria in hospitals and other health care facilities has made taking measures to prevent spread of infection even more important. The ethical implications of such measures are however all too often not taken into consideration.

 

ReAct Interview

Associate Professor Mattias Larsson on the challenges of antibiotic resistance in Vietnam

Mattias Larsson is a Swedish Associate Professor working in Vietnam. Professor Larsson expresses his concern and says it is a worrying situation in the country. In his research project they found increasing levels of resistance and high levels of colonization with Gram negative bacteria resistant to almost all available antibiotics.

News

Research project in Vietnam: results indicate very high rates of resistance to most antibiotics

In 2016-2017, ReAct supported a research project in Vietnam on preserving efficacy of last-line antibiotics. Results indicate very high rates of resistance to most antibiotics, including carbapenems.

Opinion

Mass administration of antibiotics does not solve the root cause of child mortality in Africa

The situation for many children in sub-Saharan Africa is dire: a variety of infectious diseases, malnutrition and inadequate water, sanitation and hygiene infrastructure all take their toll in these most vulnerable. According to UNICEF, the estimated mortality rate in children under 5 years in sub-Saharan Africa in 2016 was 78.4 deaths per 1000 live births. We all share a responsibility to reduce these mortality rates, but how?

Science

Rise in global antibiotic consumption between 2000 and 2015 – what can we learn from the latest study?

According to a recent publication in the Proceedings of the National Academy of Science, global antibiotic consumption in humans has increased dramatically from 2000 to 2015. The study rings a bell on the complex challenges posed by underuse, misuse and overuse of antibiotics.

 

Opinion

Towards stronger global governance for AMR

As global attention and political will to address the rising tide of antibiotic resistance has increased over the last years, and a wider range of actors starting to become involved in the field, the urgency of developing global governance of antimicrobial resistance (AMR) is growing.

ReAct Story

Caring about antibiotic resistance is similar to reducing plastic waste or saving water

“Caring about antibiotic resistance is similar to reducing plastic waste or saving water”, says Dr. Windhi Kresnawati. She is a pediatrician and has worked in a remote area in Papua Island in Indonesia for the past 4 years. During this time she managed to engage various stakeholders to support and participate in a series of activities to raise their awareness on antibiotic resistance.

 

News

The rise and fall of antibiotics?

As we recently commemorated the World Health Day, it is interesting to remind us all of the rise and approaching fall of one of the most powerful discoveries in medical history – antibiotics. What makes them so special, and why is bacterial resistance such a major threat to human health?

News

Why are fixed dose combinations of antibiotics generally not a good idea?

Fixed dose combinations are pharmaceutical products such as tablets, ointments or suspensions where two or more antibiotics are combined in one product. In the treatment of Tuberculosis and HIV, they are vital for treatment success as they improve compliance and reduce development of resistance.

In theory, it sounds like a good idea to copy this success to other bacteria and antibiotic resistance, but in practice it is generally not so.

Opinion

The ethics of antibiotic resistance

Bacterial resistance to antibiotics gives rise to new ethical problems. Much of medical ethics prior to antibiotics has been focused on whether a certain procedure is justified, for example with respect to safety, efficacy and costs. But as antibiotic resistance has a global impact that persists over time, new questions arise that cannot be solved only by more or better science. In contrast with science, which is descriptive, ethics is normative. Ethics deals with what we ought to do or ought not to do.

News

Antibiotic resistance strikes hardest at the poor

It is a well-known fact that antibiotic resistant infections have a major influence on the health of people globally. Antibiotic resistance increases both mortality and morbidity due to treatment failures and lack of effective therapy. But antibiotic resistance has even more far-reaching consequences on different levels that often tend to be overlooked.

The ReAct Toolbox

The ReAct Toolbox is a user-friendly web-based resource that provides inspiration and guidance to take action and develop national action plans on antibiotic resistance. It is built on what has been done in the past in a variety of settings, and is aligned with ongoing and current initiatives from across the globe.

We are global

ReAct is a global network of antibiotic resistance experts with nodes in Africa, Asia Pacific, Europe, Latin America and North America.

Antibiotic resistance

In the last 70 years the use of antibiotics has been crucial in improving countless lives and drastically reducing deaths caused by bacterial infections. The increasing development of antibiotic resistance is posing a serious threat to human health and development, the environment and for animal health. Learn more about ReAct’s work on antibiotic resistance here.

Stay on top of antibiotic resistance

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National Action Plans

Involved in developing your country's National Action Plan? Here you find support for developing a comprehensive plan.

Health Care Professionals

Doctors, pharmacists, veterinarians and other health care professionals - you have the power to take action! Learn more about how to get started.

Civil Society Organizations

Engagement from civil society organizations and communities is needed to tackle antibiotic resistance. Learn more about how to get involved.