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In focus

5 challenges that governments need to address in resolving the stagnation in antibiotic development

We are now well into a third decade of failure and standstill in developing new antibiotics. Meanwhile resistance to all of our existing antibiotics continues to develop across the world and antibiotic resistance was the cause of 1.2 million deaths in 2019, more than for HIV/AIDS and malaria.

The traditional market-based financing model for research and development of new antibiotics continues to fail. The reason for the lack of innovation is often presented as a matter of insufficient profitability for the pharmaceutical industry. However, there are significant scientific challenges that remain unresolved, which contributed to large pharmaceutical companies abandoning the field over the past decades.

ReAct - Action on Antibiotic Resistance

ReAct is an independent network dedicated to the problem of antibiotic resistance. ReAct is a global catalyst, advocating and stimulating for global engagement on antibiotic resistance through a broad range of collaborations.

Science

The monkeypox outbreak: Need for antibiotic stewardship?

On 23 July this year, the World Health Organization (WHO) declared that the monkeypox outbreak spreading globally is a”public health emergency of international concern” (PHEIC), the agency’s highest alarm.

Monkeypox is a viral zoonosis (it originated in animals and jumped to infect human) that causes flu-like symptoms and a blistery rash that lasts two to four weeks. A vast majority of those infected recover without severe illness, although a small percentage develop sepsis or other severe secondary infections.

Implications of monkeypox for antibiotics consumption: what can we expect?

News

ReAct Africa launches new website!

Now ReAct Africa launches its nodal website. It will help you find information about antibiotic resistance work in the African region, where the ReActnode brings together experts and key stakeholders to form technical working groups on the issue.

Learn more how ReAct Africa increases collaboration with other relevant networks and organizations and advocates for concerted action on antibiotic resistance.

Policy

New ReAct Europe and EPHA position paper on EU incentives for new antibiotics development

In a joint publication, ReAct Europe and the European Public Health Alliance (EPHA) express concerns as only a limited number of options for introducing incentives have been considered during the European Commission targeted consultations. The position paper includes 10 reasons why a TEE is not efficient for advancing antibiotic development.

In focus

Dr. Hari Paraton: Drug resistance bacteria threatens lives of mothers and newborn

In general, administering stitches to close tears on mothers who have newly delivered a child are a safe and common procedure. However, the handling of post-delivery sutures by health workers without sufficient understanding about the use of antibiotics and the risk of infection can be a different story. What are supposed to be happy moments for parents with their new born baby, after going through the delivery process, might sadly end in grief.

This was experienced by Dr Hari Paraton, an obstetrician and gynecologist from Surabaya, Indonesia, who handled a patient, (we will call her “Paramita”) with abnormal post-delivery stitches. Instead of drying out, the wound on the stitches just got worse and wider.

Policy

Allocation of adequate resources and community engagement key to NAP implementation

In 2015 recognizing the growing problem of antimicrobial resistance the World Health Organization endorsed a Global Action Plan on AMR.

The five objectives that the Global Action Plan aimed for were:

  • improving awareness and understanding of antimicrobial resistance,
  • strengthening surveillance and research,
  • reducing the incidence of infection,
  • optimizing the use of antimicrobial medicines in human and animal health and
  • ensuring sustainable investment in new medicines, diagnostic tools, vaccines, and other interventions.

How far along are we?

Research and development

The world needs new antibiotics – so why aren’t they developed?

Effective antibiotics are a cornerstone of basic and specialized medicine. The emergence of resistance in bacteria to antibiotics is slowly dismantling our ability to treat infections, alleviate human suffering, and save lives. The COVID-19 pandemic is a clear reminder of the deadly consequences the world faces, when we do not have the right treatments or vaccines available when needed.

Theme

COVID-19 and antibiotic resistance

ReAct articles relating to COVID-19 and antibiotic resistance.

Antibiotic resistance

In the last 70 years the use of antibiotics has been crucial in improving countless lives and drastically reducing deaths caused by bacterial infections. The increasing development of antibiotic resistance is posing a serious threat to human health and development, the environment and for animal health. Learn more about antibiotic resistance here.

Donate

Support us - your donation helps

Your gift means a great deal. With your donation you will help address antibiotic resistance.

We are global

ReAct is a global network of antibiotic resistance experts with nodes in Africa, Asia Pacific, Europe, Latin America and North America.

The ReAct Toolbox

The ReAct Toolbox is a user-friendly web-based resource that provides inspiration and guidance to take action and develop national action plans on antibiotic resistance. It is built on what has been done in the past in a variety of settings, and is aligned with ongoing and current initiatives from across the globe.

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Past newsletters

National Action Plans

Involved in developing and implementing your country's National Action Plan on AMR? Here you find support tools and inspiration.

Movement Building

Engagement from civil society organizations and communities is needed to tackle antibiotic resistance. Learn more about how to get involved.

Globally Coordinated Governance

Globally coordinated governance on antimicrobial resistance - to ensures a sustainable response that takes into account the conditions for LMICs

Public Health Driven Innovation

A public health driven and end-to-end approach to innovation that enables sustainable access to effective antibiotics in LMICs