In the Global Action Plan on Antimicrobial Resistance, countries are urged to improve how antibiotics are used. For the animal sector, this includes phasing out use of antibiotics for growth promotion, reducing routine use, and making sure antibiotics are used correctly when needed.
Raising food animals is fundamental for people’s livelihoods, the economy and food security, all of which will be threatened if animal diseases are not treated when needed. Antibiotic treatment is necessary for certain animal diseases to ensure survival, welfare, productivity and to reduce spread of disease.
What is rational use of antibiotics?
Rational use means to limit antibiotic use to when it is medically needed, and to use antibiotics correctly. This includes choosing the right antibiotic, at the right dose, for the right length of time. Both national and international treatment guidelines are available to help support these decisions. Ideally, these should reflect each country’s situation, including which antibiotics are available and local resistance levels. To ensure antibiotics are used sustainably in food animals; animal health, production practices and socio‑economic factors must also be considered.
Healthier animals need less antibiotics
It is common that antibiotics are given to whole groups of animals routinely to prevent or control disease outbreaks. In many cases, routine use of antibiotics is unnecessary and can be reduced by improving animal husbandry practices and biosecurity. The long-term goal of rational use efforts should be to promote a transition to farming systems where routine use of antibiotics is not needed. Learn more in Prevent infection: Food animals.
Barriers to rational use
The use of antibiotics in food animal production creates a legitimate conflict of interest. Farmers need to make a living, and may perceive that routine antibiotic use is necessary to protect productivity. Farmers may worry that being more selective in their use of antibiotics will lead to more sick animals and lower production. On the other hand, we need to reduce antibiotic use globally to limit antibiotic resistance. At the same time, growing demand for animal protein is driving an intensification of animal farming which, in turn, accelerates the use of antibiotics.
Incentives to reduce use can also be undermined. In many countries, selling antibiotics is an important source of income for animal health workers and pharmacists. Therefore, they have little motivation to discourage use. They may also worry that farmers will be dissatisfied if antibiotics are not provided. In places where the pharmaceutical market is unregulated and prescriptions are not required, high costs or limited access to veterinary advice can push farmers to treat animals themselves. In worst cases, farmers are unaware they are feeding their animals antibiotics, as these can be mixed into ready‑made feed or vitamin supplements.
Room to improve: Large variation between countries
Sales of antibiotics for veterinary use have decreased by 28% on average across Europe since 2018, with up to 60% reduction in some countries. These reductions can be attributed to factors like improved animal welfare, vaccinations, stricter biosecurity and regulations against routine antibiotic use. However, the average use is still far higher than in the lowest-using countries, such as those in Scandinavia.
Below are resources that discuss the current evidence for the negative consequences of antibiotic use in food animals and options for actions. Learn more about why and how antibiotics are used in food animal production in UNDERSTAND – Use and inappropriate use in animals and agriculture.
Selected Resources
| Resource | Description |
| WHO guidelines on use of medically important antimicrobials in food-producing animals | Recommendations from WHO on antibiotic use in animals: Discusses the evidence base and urges farmers and the food industry to stop using antibiotics routinely to promote growth and prevent disease in healthy animals. |
| Behavior-change interventions to improve antimicrobial stewardship in human health, animal health, and livestock agriculture: A systematic review | Review of studies that describe behavior-change interventions aimed at improving antimicrobial stewardship and reducing inappropriate antimicrobial use in humans, animals and agriculture. |
| Review of Evidence on Antimicrobial Resistance and Animal Agriculture in Developing Countries | Review providing available evidence on resistance in agri- and aquaculture in LMICs, highlighting the scarcity of most data and providing an overview of the gaps in knowledge. |
| Antibiotic resistance: mitigation opportunities in livestock sector development | Opinion article on rational use of antibiotics and the importance of good animal husbandry to counteract antibiotic resistance. |
| Addressing Antimicrobial Resistance: An Overview of Priority Actions to Prevent Suboptimal Antimicrobial Use in Food-Animal Production | Review that provides an overview of factors influencing farmers’ decision making and proposes priority actions against misuse of antibiotics. |
